Comparative Linkage Analysis and Visualization of High-Density Oligonucleotide SNP Array Data

Topics:
Pharmeceuticals
Tags:
Analysis,
BioMed Central,
Linkage,
Management,
Software,
Tools & Techniques
Source:
BioMed Central

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Overview: This paper reports the development of a novel software tool called Compare Linkage for automated formatting of the Affymetrix Mapping 10 K genotype data into the "Linkage" format and the subsequent analysis with multi-point linkage software programs such as Merlin and Allegro. The new software has the ability to visualize the results for all these programs in dChip in the context of genome annotations and cytoband information. In addition it reveals a variant of the Lander-Green algorithm in the dChipLinkage module of dChip software (V1.3) to perform parametric linkage analysis and haplotyping of SNP array data.

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Format: PDF | Size: 734KB | Date: Feb 2005 | Pages: 16

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