Evolution of 'Design' Principles in Biochemical Networks

Topics:
Electrical and Electronic
Tags:
Evolution,
Productivity
Source:
Institution of Electrical Engineers

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Overview: Computer modelling and simulation are commonly used to analyze engineered systems. Biological systems differ in that they often cannot be accurately characterized, so simulations are far from exact. Nonetheless, we argue in this paper that evolution results in recurring, dynamic organizational principles in biological systems, and that simulation can help to identify them and analyze their dynamic properties. As a specific example, we present a dynamic model of the galactose utilization pathway in yeast, and highlight several features of the model that embody such 'design principles'.

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Format: PDF | Size: 751KB | Date: Jun 2004 | Pages: 13

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