Autonomously Oscillating Biochemical Systems: Parametric Sensitivity of Extrema and Period

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Source:
Institution of Electrical Engineers

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Overview: This paper addresses sensitivity analysis of autonomously oscillating biochemical systems. Building on results from the engineering literature, a general analysis is presented which addresses key features of oscillatory trajectories, namely the period and local maximum or minimum values of species concentrations and reaction rates. A discussion of sensitivity invariants generalizes results from steady-state sensitivity analysis to this context. The results are illustrated by the application to a model of a circadian oscillator.

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Format: PDF | Size: 171KB | Date: Jun 2004 | Pages: 9

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