Strategy for the Synthesis of Polymeric Supports With Hydrazone Linkers for Solid-Phase Alkylation of Ketones and Aldehydes
- Topics:
- Chemical
- Source:
- American Chemical Society
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Overview: A new approach to polymeric supports useful for the immobilization of aldehydes and ketones via hydrazone linkers is reported. The new strategy gives supports with better properties and is effective for the synthesis of all supports previously used for the alkylation of ketones anchored as hydrazones. The supports were used for immobilization of ketones 3-pentanone, acetone, N-benzylpiperidone, and aldehydes hexanal and 3-phenylpropanal in the form of their hydrazones. The polymer-supported hydrazones were subjected to R-alkylation (LDA/RX) followed by acidic, reductive, or oxidative cleavage/workup procedures to provide R-alkylated aldehydes or ketones as well as corresponding primary amines, alcohols, nitriles or acids.
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Format: PDF | Size: 274KB | Date: Nov 2004 | Pages: 8
