Amygdala-Hippocampal Shape Differences in Schizophrenia: The Application of 3D Shape Models to Volumetric MR Data

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Overview: Evidence suggests that some structural brain abnormalities in schizophrenia are neuro developmental in origin. There is also growing evidence to suggest that shape deformations in brain structure may reflect abnormalities in neurodevelopment. While many magnetic resonance (MR) imaging studies have investigated brain area and volume measures in schizophrenia, fewer have focused on shape deformations. In this MR paper they used a 3D shape representation technique, based on spherical harmonic functions, to analyze left and right amygdala-hippocampus shapes in each of 15 patients with schizophrenia and 15 healthy controls matched for age, gender, handedness and parental socio economic status.

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Format: PDF | Size: 1,597KB | Date: Aug 2002 | Pages: 21

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