Voxel-Based Morphometric Analysis of Gray Matter in First Episode Schizophrenia

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Reed Elsevier Inc.
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Reed Elsevier

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Overview: Voxel-based morphometry (VBM) may afford a more rapid and extensive survey of gray matter abnormalities in schizophrenia than manually drawn region of interest (ROI) analysis, the current gold standard in structural MRI. Unfortunately, VBM has not been validated by comparison with ROI analyses, nor used in first-episode patients with schizophrenia or affective psychosis, who lack structural changes associated with chronicity. An SPM99-based implementation of VBM was used to compare a group of 16 patients with first-episode schizophrenia and a group of 18 normal controls and, as a further comparison, 16 first-episode patients with affective psychosis.

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Format: PDF | Size: 387KB | Date: Dec 2002 | Pages: 9

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