Cingulate Fasciculus Integrity Disruption in Schizophrenia: A Magnetic Resonance Diffusion Tensor Imaging Study

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Society Of Biological Psychiatry,
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Society of Biological Psychiatry

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Overview: Evidence suggests that a disruption in limbic system network integrity and, in particular, the cingulate gyrus (CG), may play a role in the pathophysiology of schizophrenia; however, the cingulum bundle (CB), the white matter tract furnishing both input and output to CG, and the most prominent white matter fiber tract in the limbic system, has not been evaluated in schizophrenia using the new technology of diffusion tensor imaging (DTI). These data provide strong evidence for CB disruptions in schizophrenia, which may be related to disease-related attention and working memory abnormalities.

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Format: PDF | Size: 223KB | Date: Nov 2003 | Pages: 10

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