Abnormal Neural Synchrony in Schizophrenia
- Topics:
- Healthcare Services
- Source:
- Society for Neuroscience
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Overview: Schizophrenia has been conceptualized as a failure of cognitive integration, and abnormalities in neural circuitry have been proposed as a basis for this disorder. They used measures of phase locking and phase coherence in the scalp-recorded electroencephalogram to examine the synchronization of neural circuits in schizophrenia. Compared with matched control subjects, schizophrenia patients demonstrated: absence of the posterior component of the early visual gamma band response to Gestalt stimuli; abnormalities in the topography, latency, and frequency of the anterior component of this response; delayed onset of phase coherence changes; and the pattern of anterior-posterior coherence increases in response to Gestalt stimuli found in controls was replaced by a pattern of inter-hemispheric coherence decreases in patients.
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Format: PDF | Size: 311KB | Date: Aug 2003 | Pages: 5
