Evaluating Noncancer Effects of Trichloroethylene: Dosimetry, Mode of Action, and Risk Assessment

Topics:
Healthcare Services
Tags:
Judgment,
Management,
Risk Assessment,
Security,
Strategy,
Tools & Techniques
Source:
The AEgis Technologies Group

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Overview: This paper discusses the alternatives for developing chronic exposure limits for noncancer effects of trichloroethylene (TCE). These alternatives were organized within a framework for dose-response assessment - exposure: dosimetry (pharmacokinetics): mode of action (pharmacodynamics): response. This framework provides a consistent structure within which to make scientific judgments about available information, its interpretation, and use. These judgments occur in the selection of critical studies, internal dose metrics, pharmacokinetic models, approaches for interspecies extrapolation of pharmacodynamics, and uncertainty factors.

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Format: PDF | Size: 1,270KB | Date: May 2000 | Pages: 12

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